NCAM polysialic acid can regulate both cell-cell and cell-substrate interactions.

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NCAM polysialic acid can regulate both cell-cell and cell-substrate interactions

We have proposed previously that the polysialic acid (PSA) moiety of NCAM can influence membrane-membrane apposition, and thereby serve as a selective regulator of a variety of contact-dependent cell interactions. In this study, cell and tissue culture models are used to obtain direct evidence that the presence of PSA on the surface membrane can affect both cell-cell and cell-substrate interact...

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NCAM and its polysialic acid moiety: a mechanism for pull/push regulation of cell interactions during development?

Many cell adhesion molecules have a distinct pattern of expression and well-defined role in cell-cell recognition. In contrast, NCAM is broadly expressed and perturbations of its function affect many diverse aspects of embryonic development. Evidence has been obtained suggesting that the molecule and its polysialic acid moiety serve not only to contribute to specific interactions, but also to r...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1991

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.114.1.143